What is Icosapent Ethyl?

Icosapent Ethyl (also known as EPA-E or EPA-ethylester) is a prescription medication used to reduce high levels of triglycerides in the blood. It is a form of eicosapentaenoic acid (EPA), an omega-3 fatty acid found in fish and other seafood.

EPA-E works by decreasing the production of triglycerides in the liver and increasing the breakdown of triglycerides in the blood. It is usually taken twice daily, with or without food.

Vascepa (Icosapent Ethyl) is a powerful way to help lower high triglycerides in your body. Unlike traditional fish oil supplements, Vascepa contains just one type of omega-3 fatty acid – EPA - making it more concentrated and effective at reducing elevated fat levels.

Plus, when used with an appropriate low-fat/low cholesterol diet plan, you can experience the convenient health benefits of this advanced nutritional tool! Vascepa or Icosapent Ethyl is only available by prescription.

What is the difference between Icosapent Ethyl and Fish Oil?

Icosapent Ethyl (also known as EPA-only or pure EPA) is a prescription medication made from a highly purified form of omega-3 fatty acid called eicosapentaenoic acid (EPA).

Fish oil, on the other hand, is a dietary supplement that contains both EPA and another omega-3 fatty acid called docosahexaenoic acid (DHA). EPA is believed to be the most important omega-3 fatty acid for reducing inflammation and improving cardiovascular health. DHA is important for brain and eye health.

Is Over-the-Counter Fish Oil as affective as Icosapent Ethyl for heart health?

The short answer is yes, Over the Counter (OTC) fish oil can be as effective as Icosapent Ethyl for heart health. However, before considering any changes to your health regimen it’s important to consult with your doctor who can best advise whether OTC or prescription fish oil supplements are right for you.

That being said, studies have consistently shown that both prescription forms and OTC versions offer significant benefits when taken at suggested dosages on a regular basis over long periods of time.

Studies suggest that people who regularly consume omega-3 fatty acids have lower rates of cardiac events than those who do not take omega-3 supplements consistently each day over months or even years due to their anti-inflammatory effects which protect against atherosclerosis—the buildup of plaque within arteries which can cause clots leading to coronary artery disease.  

Wondering what to do to keep your heart healthy? Fish oil is the answer! Check out our top 7 picks for fish oil supplements to keep your heart beating strong!


Finding the right omega-3 supplement can be tricky because there are so many different brands and types available. How do you know which one will give you the best value for your money?

Our team reads hundreds of reviews on Amazon to find the best products for your needs. We've done all the hard work so that you can easily find and purchase the perfect supplement for better heart health.

Here Are Our Top 7 Picks.

Nature's Bounty Fish Oil

Supports Heart Health, 1200 Mg, Rapid Release Softgels, 200 Ct 78,695 ratings

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Why We Love It:  

Nature's Bounty Fish Oil Softgels provide important Omega-3 fatty acids including EPA and DHA which help to support and maintain the health of your cardiovascular system. Plus, these softgels are easy to take and are purified to eliminate mercury, making them a perfect way to obtain important Omega-3 fatty acids in a convenient form.

What You Should Know:

Nature's Bounty Softgels are heart health supplements that are backed by 50 years of dedication to quality, consistency and scientific research. They are free from shellfish, gluten, lactose, sugar and artificial colours and sweeteners.

Plus, they contain 360 mg of Omega-3 EPA & DHA for healthy cellular and metabolic support. Get your Nature's Bounty Fish Oil Softgels today and give your heart the support it needs!

Omega 3 Fish Oil 4,080mg

High EPA 1200mg + DHA 900mg Triple Strength Burpless Softgels - Arazo Nutrition (120 Soft Gels)
Amazon’s Choice 26,500 ratings

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Why We Love It:

If you want to imporove your heart health and your overall wellbing, Omega 3 Fish Oil from Arazo Nutrition might be just what you need! This fish oil is made from wild ocean caught fish, with high doses of 4,080mg Omega 3 fatty acids and 2,250mg total Omega 3.

Plus, it is ultra-purified and refined to ensure that it is free from heavy metals, mercury, and PCBs.

What You Should Know:

This product also has a natural lemon flavor which makes it burpless and easy to swallow without any fishy aftertaste. It also has extremely low oxidation levels, making it one of the freshest fish oils available in the market.

And it is made in a GMP certified facility in America and is heavy metal tested for purity.  Get Omega 3 Fish Oil from Arazo Nutrition today!

Nordic Naturals Ultimate Omega

Lemon Flavor - 1280 mg Omega-3 - High-Potency Omega-3 Fish Oil with EPA & DHA - Promotes Brain & Heart Health - Non-GMO
42,753 ratings #1 Best Seller in Omega 3 Nutritional Supplements

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Why We Love It:

Say hello to the ultimate omega-3 formula! Nordic Naturals Ultimate Omega is a high concentration fish oil supplement designed to support heart health. It contains essential fatty acids EPA and DHA, which have been known to support heart, brain, eye, and immune health.

Plus, it may help support a healthy mood. This formula has been recommended by doctors and meets the daily recommended dose suggested by the American Heart Association.

What You Should Know:

Nordic Naturals Ultimate Omega features an easy-to-absorb triglyceride molecular form for optimal absorption and has a great lemon taste that won't give you any fishy burps.

Plus, it's crafted from fresh, wild-caught omega-rich fish and is non-GMO, gluten- and dairy-free with no artificial colors, flavors, or preservatives. It's the perfect supplement to support your heart health and overall wellbeing. So why wait? Get your own bottle of Nordic Naturals Ultimate Omega today!

Nature Made Fish Oil 1000 mg

250 Softgels Value Size, Omega 3 Supplement For Heart Health 34,218 ratings Amazon's Choice for "fish oil"

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Why We Love It:

Nature Made Fish Oil 1000 mg Softgels are an excellent supplement to support your heart health. Each serving provides 600 mg Omega-3 fatty acids (500 mg EPA and DHA) to help support a healthy heart.

These fish oil softgels are purified to remove mercury and other contaminants, and they are also gluten free, dairy free, and have no color added or artificial flavors. Plus, they are USP verified, making them the Number 1 Pharmacist Recommended Vitamin & Supplement Brand.

What You Should Know:

These Softgels are the perfect choice for those wanting to take control of their heart health. They come in a convenient 250 count bottle so you can get a 125-day supply.

Adults should take two of these amazing softgels daily with water and a meal to achieve optimal heart health. With Nature Made Fish Oil 1000 mg Softgels, you can trust that you are getting the highest quality ingredients for your heart health.

Sports Research Triple Strength Omega 3 Fish Oil 

Burpless Fish Oil Supplement w/EPA & DHA Fatty Acids from Wild Alaskan Pollock - Heart, Brain & Immune Support for Men & Women - 1250 mg - 36,543 ratings #1 Best Seller in Essential Fatty Acid Combination Nutritional Supplements

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Why We Love It:

This Fish Oil is the perfect choice for those who want to get the most out of their daily omega 3 supplement. Their easy-to-swallow softgels contain ultra-concentrated Omega 3 fatty acids from wild-caught natural Alaskan Pollock, providing essential fatty acids for heart health, brain function and immune system support.

These omega 3 supplements are non-GMO verified and IFOS 5-star certified, so you can be sure that you're getting the highest quality fish oil. Plus, their omega 3 fish oil supplements are made right here in the USA in a cGMP certified facility, so you can trust that they're safe, effective, and superior.

What You Should Know:

Not only is this Triple Strength Omega 3 Fish Oil the ideal supplement for adults, men or women alike, but it also won't cause any fish burps or fishy aftertaste. Plus, this high-quality fish oil supplement is pescatarian friendly, so it can be easily incorporated into any diet.

With just one capsule, you can get all of the health benefits of Omega 3 fatty acids with no hassle. So why wait? Get your own Sports Research Triple Strength Omega 3 Fish Oil today and get on the path to better health!

Viva Naturals Triple-Strength Wild Caught Fish Omega-3 Fish Oil

with EPA and DHA Supplement, 2000 mg Omega 3 Fatty Acids per Serving, 180 Softgels - 8,684 ratings

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Why We Love It:

This Fish Oil is a must-have for those looking for heart health support. This omega-3 supplement is highly concentrated to give you clean, high-quality oil with no fishy aftertaste.

Each daily serving of 2 softgels provides 2,200 mg of fish oil, including 1,400 mg of EPA and 480 mg of DHA. Plus, its omega-3 fatty acids are delivered in triglyceride form, which has been scientifically shown to be more easily absorbed by your body.

What You Should Know:

It is designed to give you maximum absorption and maximum benefits. Their fish are wild caught using sustainable fishing practices – never farm raised. Plus, they use a combination of small fish (like sardines, anchovies, and mackerel) known to have less accumulation of mercury and other toxins than some bigger fish.

These softgels are IFOS Certified, gluten-free, and Non-GMO for quality, purity, and potency, so you can trust you’re getting the highest quality. Get Viva Naturals Triple-Strength Wild Caught Fish Omega-3 Fish Oil and support your heart, brain, skin, and eyes health today!

Omega-3 Fish Oil Supplement 3600 mg

EPA & DHA | Best Source of Omega 3 | Ultimate Brain, Joint, & Eye Health Support for Men & Women | Non GMO Burpless Lemon Softgel Capsules 2000mg Plus (120 Pills) - 18,539 ratings

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Why We Love It:

MAV Fish Oil's Omega-3 Fish Oil Supplement is a must-have for anyone looking for a natural way to support their heart health. This powerful supplement contains unique essential fatty acids, including EPA and DHA, which can reduce inflammation and boost overall health and wellness.

Plus, with 3600mg of Fish Oil per serving, it contains more EPA and DHA than competing brands. Even better, it's a 100% natural and pure formula with no additives, and it has a burpless formula, so it won't cause stomach upset or an unpleasant aftertaste.

What Else Should People Know:

MAV Fish Oil Supplement is made from pure sea-harvested pelagic fish oil, so you get all the health benefits of 100% pure fish oil. This powerful supplement is great for supporting brain health, healthy joints, mood, skin, hair, and more.

Plus, it's infused with a refreshing natural lemon flavor that helps to mask the fishy taste. So, try MAV Fish Oil's Omega-3 Fish Oil Supplement today and take your health to the next level!

Fish Oil FAQ:

Are you looking for a supplement to help with your overall health but don't know which one to choose? Icosapent ethyl is an omega-3 fatty acid supplement that has been shown to help with inflammation, cardiovascular health, and more, available by prescription only.

But when you don't need prescription strength, the fish oil supplements are a great alternative. There are many brands to choose from and you may not know which one is right for you. That's why we've compiled a list of the most frequently asked questions about icosapent ethyl and fish oil supplements so you can know more about it and how it can help you.

What is Icosapent Ethyl?

Icosapent Ethyl (also known as EPA-E) is a highly purified form of eicosapentaenoic acid (EPA), an omega-3 fatty acid found in fish oil. It is used to reduce high triglyceride levels in adults with severe hypertriglyceridemia, a type of fat in the blood. 

It is also used to reduce the risk of cardiovascular events, such as heart attack and stroke, in adults with high levels of triglycerides and established cardiovascular disease. It is only available with a prescription.

What does pescatarian mean?

A pescatarian is a type of vegetarian who doesn't skimp on the good stuff! They enjoy adding fish and other types of seafood to their plant-based diets. 

The word "pesce" means “fish” in Italian, so these individuals are also known as pesco-vegetarians or pescatarians. Eating this way has numerous health benefits -- transition your diet today for an ocean full of nutrients!

How does fish oil help the heart?

Fish oil is a rich source of omega-3 fatty acids, which have been shown to reduce inflammation in the body, reduce triglycerides, and reduce blood pressure. These effects help to protect the heart from damage and reduce the risk of cardiovascular disease. Omega-3 fatty acids also help to reduce the risk of arrhythmias, which can lead to heart attack or stroke. Additionally, omega-3 fatty acids can help to reduce plaque buildup in the arteries, which can lead to atherosclerosis and heart attack.

What is the best kind of fish oil?

The best kind of fish oil is one that is high in omega-3 fatty acids, specifically EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid). These omega-3 fatty acids have been shown to have a variety of health benefits, including reducing inflammation and improving cardiovascular health. The best sources of omega-3 fatty acids are cold-water fish, such as salmon, mackerel, herring, and sardines, as well as supplements derived from these fish.

What is Omega 3?

Omega 3 is a type of polyunsaturated fatty acid found in certain foods, such as fatty fish, flaxseed, walnuts, and chia seeds. Omega 3 fatty acids are essential for good health and are known to reduce inflammation, lower cholesterol, and reduce the risk of heart disease.


After reviewing seven Omega-3 Fish Oil products, we believe that there's a product that will meet everyone's needs. Whether you're looking for a product with a higher dosage, a low price, or a unique delivery method, there's something here for you. With its many benefits, fish oil can help to improve cardiovascular health and reduce inflammation.

So don't hesitate to give it a try! Explore the options above and find the one that works best for you. Be sure you consult with your health care provider on what is best for you, whether you need prescription strength, Icosapent Ethyl or a supplement.

Unlocking the Secrets of a Heart Healthy Diet